ASSOCIATION OF BRAF V600E MUTATION WITH POOR CLINICOPATHOLOGICAL OUTCOMES IN 500 CONSECUTIVE CASES OF PAPILLARY THYROID CARCINOMA.

摘要

In this study, BRAF mutation was found in 219 of 500 cases (43.8%). In particular, we found the most common BRAF V600E mutation in 214 cases (42.8%), BRAF K601E mutation in three cases (0.6%), BRAF VK600–1E (0.2%) in one case, whereas in one case we found a new 14-bp deletion with concomitant 2-bp insertion, VKSR600–3del and T599I, respectively. BRAF V600E was associated with extrathyroidal invasion (P 0.0001), multicentricity (P 0.0026), presence of nodal metastases (P 0.0009), class III vs. classes I and II (P 0.00000006), and absence of tumor capsule (P 0.0001), in particular in follicular- and micro-PTC variants. By multivariate analysis, the absence of tumor capsule remained the only parameter associated (P 0.0005) with BRAF V600E mutation.